The Role of Hydrogen in Managing Parkinson’s Disease

inhalation-h2-molecular-gas

Oxidative stress is a significant factor in the progression of Parkinson’s disease (PD). Recent studies have revealed the antioxidant properties of molecular hydrogen (H2) in cultured cells and animal models. Drinking H2-dissolved water (H2-water) has been shown to reduce oxidative stress and improve PD symptoms in model animals.

In a placebo-controlled, randomized, double-masked, parallel-group clinical pilot study, the authors evaluated the efficacy of H2-water in Japanese patients with levodopa-medicated PD. Participants drank 1,000 mL/day of H2-water or pseudo water for 48 weeks.

The study found an improvement in the Total Unified Parkinson’s Disease Rating Scale (UPDRS) scores in the H2-water group (n=9), whereas the scores worsened in the placebo group (n=8). Despite the small sample size and the short duration of the trial, the difference was significant (P<0.05).

This research suggests that drinking H2-water is safe and can significantly improve total UPDRS scores for PD patients.

References:

Dexter DT, Wells FR, Agid F, Agid Y, Lees AJ, Jenner P, Marsden CD. Increased nigral iron content in postmortem Parkinsonian brain. Lancet 1987; 8569: 1219– 1220.
Yoritaka A, Hattori N, Uchida K, Tanaka M, Stadtman ER, Mizuno Y. Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson’s disease. Proc Natl Acad Sci U S A 1996; 93: 2696– 2701.
Ohsawa I, Ishikawa M, Takahashi K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 2007; 13: 688– 694.
Ohta S. Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with the potential for improving mitochondrial diseases. Biochim Biophys Acta 2012; 1820: 586– 594.
Fujita K, Seike T, Yutsudo N, et al. Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease [serial online]. PLoS One 2009; 30: e7247.
Fu Y, Ito M, Fujita Y, et al. Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease. Neurosci Lett 2009; 453: 81– 85.
Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinicopathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992; 55: 181– 184.
Nagata K, Nakashima-Kamimura N, Mikami T, Ohsawa I, Ohta S. Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. Neuropsychopharmacology 2009; 34: 501– 508.
Shimouchi A, Nose K, Shirai M, Kondo T. Estimation of molecular hydrogen consumption in the human whole body after ingesting hydrogen-rich water. Adv Exp Med Biol 2012; 737: 245– 250.
Ohno K, Ito M, Ichihara M, Ito M. Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other disease [serial online]. Oxid Med Cell Longev 2012; 2012: 353152.

1     2  3 4    

5  

6

This entry was posted in Hydrogen and tagged , , . Bookmark the permalink.